Protein-complex {ubiquitin ligase complex} substrate-recognition components are in proteolytic pathways {ubiquitin/proteasome proteolytic pathway}. Ubiquitination attaches 76-amino-acid peptides {ubiquitin, complex} to proteins. The 26S proteasome then degrades ubiquitin and protein. Ubiquitin/proteasome proteolytic pathway decreases cell-cycle-regulation, cell-proliferation, differentiation, and development proteins.
Ubiquitin/proteasome proteolytic pathway has ubiquitin-activating enzymes {E1 gene}.
Ubiquitin/proteasome proteolytic pathway has ubiquitin-conjugating enzymes {E2 gene}.
Ubiquitin/proteasome proteolytic pathway has ubiquitin ligases {E3 gene}, such as SCF types. Ubiquitin ligase connects cell-cycle protein to ubiquitin and controls protein level.
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Date Modified: 2022.0225